Search Result

Results for "

Antiproliferative activities

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) ADC Cytotoxin (3) Adenosine Receptor (1) Adrenergic Receptor (1) Akt (5) Aldehyde Dehydrogenase (ALDH) (2) Amino Acid Derivatives (1) Aminopeptidase (1) AMPK (3) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (2) Androgen Receptor (3) Antibiotic (16) Apoptosis (163) Atg7 (1) Atg8/LC3 (1) ATM/ATR (2) Aurora Kinase (5) Autophagy (20) Bacterial (28) Bcl-2 Family (8) Bcr-Abl (5) Biochemical Assay Reagents (1) BRK (1) Btk (9) c-Fms (1) c-Kit (4) c-Met/HGFR (10) c-Myc (2) Carbonic Anhydrase (14) Casein Kinase (3) Caspase (10) CD73 (1) CDK (29) Ceramidase (1) CFTR (1) Checkpoint Kinase (Chk) (2) Cholinesterase (ChE) (1) COX (3) Cryptochrome (1) CXCR (1) Cytochrome P450 (3) Deubiquitinase (2) Dihydroorotate Dehydrogenase (1) DNA Alkylator/Crosslinker (1) DNA-PK (3) DNA/RNA Synthesis (12) Dopamine Receptor (6) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) DYRK (2) EBV (1) EGFR (28) Endogenous Metabolite (5) Epigenetic Reader Domain (16) ERK (6) Estrogen Receptor/ERR (2) Eukaryotic Initiation Factor (eIF) (2) FAK (6) Fat Mass and Obesity-associated Protein (FTO) (1) Fatty Acid Synthase (FASN) (1) Ferroptosis (2) FGFR (4) Flavivirus (1) FLT3 (12) Fungal (10) Gli (1) Glutaminase (2) Glutathione Peroxidase (2) HBV (2) HDAC (24) Hedgehog (3) HIF/HIF Prolyl-Hydroxylase (4) Histone Acetyltransferase (4) Histone Demethylase (8) Histone Methyltransferase (7) HIV (2) HPV (1) HSP (7) HSV (2) HuR (1) ICMT (1) IFNAR (1) IGF-1R (1) Influenza Virus (3) Interleukin Related (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (4) Itk (1) JAK (9) JNK (1) Keap1-Nrf2 (2) Kinesin (3) Lactate Dehydrogenase (1) Ligands for Target Protein for PROTAC (1) Lipoxygenase (1) LXR (1) mAChR (1) MALT1 (1) MAP3K (1) MAPKAPK2 (MK2) (1) MDM-2/p53 (6) MEK (3) MELK (1) Methionine Adenosyltransferase (MAT) (1) MicroRNA (1) Microtubule/Tubulin (42) Mitochondrial Metabolism (5) Mitophagy (2) MMP (2) Monoamine Oxidase (1) Mps1 (3) mTOR (2) Necroptosis (2) NF-κB (2) NO Synthase (2) Notch (1) Nucleoside Antimetabolite/Analog (3) Oxidative Phosphorylation (1) P-glycoprotein (1) p38 MAPK (2) p62 (1) PAK (1) Parasite (4) PARP (7) PDGFR (5) PERK (2) Phosphatase (4) Phosphodiesterase (PDE) (5) PI3K (11) Pim (5) PKC (4) Platelet-activating Factor Receptor (PAFR) (1) Polo-like Kinase (PLK) (8) Potassium Channel (1) PROTACs (19) Proteasome (2) Proton Pump (1) Pyroptosis (1) Pyruvate Kinase (1) Raf (5) Ras (9) Reactive Oxygen Species (14) RET (1) ROR (1) SARS-CoV (4) SHP2 (1) Sirtuin (1) Smo (2) Somatostatin Receptor (6) SphK (1) Src (3) SRPK (1) STAT (10) Steroid Sulfatase (1) Syk (1) TAM Receptor (1) TGF-beta/Smad (1) Topoisomerase (17) Trk Receptor (8) TrxR (1) Tyrosinase (3) VD/VDR (1) VEGFR (10) WDR5 (1) Wnt (2) YAP (2) β-catenin (1)
By Research Areas:	Cancer (569) Cardiovascular Disease (7) Endocrinology (6) Infection (48) Inflammation/Immunology (36) Metabolic Disease (13) Neurological Disease (17)
Click Chemistry:	Alkynes (2)

621

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156777

Antiproliferative agent-36	Others	Cancer
Antiproliferative agent-36 (compound 8i) is a benzothiazolyl hydrazones derived compound with antiproliferative activity. Antiproliferative agent-36 has a broad-spectrum anticancer activity .

HY-N11916

Kadsuphilin A

Others Cancer

Kadsuphilin A can be extracted from Kadsura coccinea (Lem.) and has weak antiproliferative activity .

Kadsuphilin A	Others	Cancer
Kadsuphilin A can be extracted from Kadsura coccinea (Lem.) and has weak antiproliferative activity .

HY-156843

Antiproliferative agent-38	Others	Cancer
Antiproliferative agent-38 (com 18) is a tetracyclic ring, but its most reactive ring nitrogen (probably the quinoline moiety) cannot undergo N-alkylation. Antiproliferative agent-38 lacks anti-malarial activity and lacks anti-cancer cell proliferation activity .

HY-146184

CCT373567

Bcl-2 Family Cancer

CCT373567 is a potent degrader of transcriptional repressor BCL6, with an IC₅₀ of 2.9 nM. CCT373567 exhibits antiproliferative activity .

CCT373567	Bcl-2 Family	Cancer
CCT373567 is a potent degrader of transcriptional repressor BCL6, with an IC₅₀ of 2.9 nM. CCT373567 exhibits antiproliferative activity .

HY-N1107

Uzarigenin NSC 119993; NSC 277290; Odorigeni	Others	Cancer
Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC₅₀ values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively .

HY-115948

Antitumor agent-46	Others	Cancer
Antitumor agent-46 (Compound 2h) is an anti-tumor agent. Antitumor agent-46 demonstrates markedly higher antiproliferative activity on MCF-7 cells with an IC₅₀ value of 2.08 µM .

HY-149032

Kobusine derivative-1

Others Cancer

Kobusine derivative-1 is a Kobusine derivative. Kobusine derivative-1 shows antiproliferative activities against cancer cells .

Kobusine derivative-1	Others	Cancer
Kobusine derivative-1 is a Kobusine derivative. Kobusine derivative-1 shows antiproliferative activities against cancer cells .

HY-143463

AC-386	c-Met/HGFR	Cancer
AC-386 is a highly potent c-Met inhibitor with IC₅₀ value of 7.42 nM. AC-386 has antiproliferative activities against certain cancer cell lines. AC-386 can be used for researching anti-cancer resistance .

HY-N0005S

Curcumin-d6 Diferuloylmethane-d₆; Natural Yellow 3-d₆; Turmeric yellow-d₆	Keap1-Nrf2 Ferroptosis Autophagy Histone Acetyltransferase Epigenetic Reader Domain Mitophagy Influenza Virus	Infection Metabolic Disease Inflammation/Immunology
Curcumin-d₆is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

HY-136521

AZ13824374	Epigenetic Reader Domain	Cancer
AZ13824374 is a highly potent and selective ATAD2 bromodomain inhibitor which shows cellular target engagement and antiproliferative activity in a range of breast cancer models. AZ13824374 inhibits ATAD2 with pIC₅₀s of 8.2 and 6.2 in ATAD2 FRET assay and ATAD2 NanoBRET assay, respectively .

HY-144807

Carbonic anhydrase inhibitor 9	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 9 is a potent carbonic anhydrase (CA) inhibitor with K_is of 56.4 and 56.9 nM for hCA II and IX, respectively. Antiproliferative activity .

HY-146020

Topoisomerase IIα-IN-1	Topoisomerase	Cancer
Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines .

HY-118834

Teleocidin A1 Lyngbyatoxin A	PKC	Cancer
Teleocidin A1 (Lyngbyatoxin A), a highly toxic skin irritant, is a potent activator of protein kinase C (PKC). Teleocidin A1 shows antiproliferative activity against HeLa cancer cells (IC₅₀=9.2 nM) .

HY-161030

EGFR-IN-92	EGFR	Cancer
EGFR-IN-92 (compound 15) is an allosteric T790M/L858R double mutant EGFR inhibitor. EGFR-IN-92 shows antiproliferative activity against H1975 non-small lung cancer (NSCLC) cancer cells expressing double mutant EGFR .

HY-143462

c-Met/HDAC-IN-2	HDAC c-Met/HGFR Apoptosis	Cancer
c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC₅₀s of 18.49 nM and 5.40 nM for HDAC1 and c-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certain cancer cell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induce apoptosis in HCT-116. c-Met/HDAC-IN-2 can be used for researching anti-cancer resistance .

HY-163105

Tubulin/NEDDylation-IN-1	Microtubule/Tubulin	Cancer
Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of tubulin (Microtubule/Tubulin)-NEDDylation (IC₅₀ for tubulin=2.40 μM), which has strong anti-proliferative activity. Neddylation is a protein post-translational modification that covalently tags the ubiquitin-like protein NEDD8 to target proteins. Tubulin/NEDDylation-IN-1 forms hydrogen bonds with residues of tubulin and E1 NEDD8 activating enzyme (NAE) through methoxy and dithiocarbamate groups and inhibits NEDDylation and microtubulin in an ATP-dependent manner. tube polymerization .

HY-155359

Tubulin polymerization-IN-55	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-55 is a potent inhibitor of Tubulin Polymerization. Tubulin polymerization-IN-55 has antiproliferative activity against A549, K562, HepG2, MDA-MB-231 and HFL-1 with IC₅₀ s of 8, 3, 9, 24 and 62 nM, respectively .

HY-146021

Topoisomerase IIα-IN-2	Topoisomerase	Cancer
Topoisomerase IIα-IN-2 (compound 5) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-2 exhibits high antiproliferative activity against human cancer cell lines. Topoisomerase IIα-IN-2 significantly induces DNA damage and arrests cancer cells at G2/M phase .

HY-146884

MET kinase-IN-3	c-Met/HGFR VEGFR	Cancer
MET kinase-IN-3 (compound 8) is an orally active and potent MET inhibitor, with an IC₅₀ of 9.8 nM. MET kinase-IN-3 shows good and broad-spectrum antiproliferative activity against cancer cell lines .

HY-155841

Tubulin polymerization-IN-46	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-46 (compound 9q) is a microtubule/Tubulin inhibitor that inhibits tubulin polymerization and induces apoptosis. Tubulin polymerization-IN-46 inhibits mitosis and arrests MCF-7 cells in the G2/M phase. Tubulin polymerization-IN-46 has anti-proliferative activity against MCF-7 breast cancer cells with an IC₅₀ of 10 nM .

HY-145406

IHCH-3064	Adenosine Receptor HDAC	Inflammation/Immunology Cancer
IHCH-3064 is a dual-acting compounds targeting Adenosine A2A Receptor and HDAC. IHCH-3064 exhibits potent binding to A2AR (Ki=2.2 nM) and selective inhibition of HDAC1 (IC50=80.2 nM), with good antiproliferative activity against tumor cell lines in vitro. IHCH-3064 is a tumor immunotherapeutic agent.

HY-146807

Type II TRK inhibitor 1	Trk Receptor	Cancer
Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKA ^G667C and ETV6-TRKC ^G696C fusion proteins with IC₅₀s of 6 nM and 1.7 nM, respectively . Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-115944

BTK-IN-9	Btk Apoptosis	Inflammation/Immunology Cancer
BTK-IN-9 is a reversible BTK inhibitors with potent antiproliferative activity in mantle cell lymphoma. BTK-IN-9 specifically disturbs mitochondrial membrane potential and increases reactive oxygen species level in Z138 cells. BTK-IN-9 also induces cell apoptosis in Z138 cells .

HY-150543

Steroid sulfatase-IN-3	Steroid Sulfatase	Cancer
Steroid sulfatase-IN-3 (compound 1q) is a potent STS (Steroid sulfatase) inhibitor, with an IC₅₀ of 25.8 nM. Steroid sulfatase-IN-3 shows antiproliferative activity against T-47D estrogen-dependent breast cancer cells, with an IC₅₀ of 1.04 µM .

HY-N9093

(3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane	Others	Inflammation/Immunology Cancer
(3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane, a diarylheptanoid from the rhizomes of Curcuma kwangsiensis, possesses a variety of biological and pharmacological activities including antioxidant, antihepa totoxic, anti-inflammatory, antiproliferative, antiemetic, and antitumor activities .

HY-150688

JAK3-IN-13	JNK	Cancer
JAK3-IN-13 is a potent, selective and orally active JAK3 inhibitor with IC₅₀ values of 4728, 2039, 8, 365 nM for NK1, JNK2, JNK3, Tyk2, respectively. JAK3-IN-13 shows antiproliferative activity. JAK3-IN-13 induces cell cycle arrest at G0/G1 phase. JAK3-IN-13 shows antitumor activity .

HY-152090

Antiproliferative agent-17	Bacterial Sirtuin	Infection Cancer
Antiproliferative agent-17 is an antiproliferative agent. Antiproliferative agent-17 inhibits Gram-positive bacteria and has anticancer activity .

HY-146683

KS106	Aldehyde Dehydrogenase (ALDH) Apoptosis	Cancer
KS106 is a potent ALDH inhibitor with IC₅₀s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase .

HY-146682

KS100	Aldehyde Dehydrogenase (ALDH) Apoptosis	Cancer
KS100 is a potent ALDH inhibitor with IC₅₀s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase .

HY-147776

Antiproliferative agent-8	MDM-2/p53	Cancer
Antiproliferative agent-8 (Compound 5a) is an anti-cancer agent. Antiproliferative against-8 has antiproliferative activity. Antiproliferative agent-8 significantly increases the P53 levels .

HY-142085

Antiproliferative agent-20	Others	Cancer
Antiproliferative agent-20 is a potent and orally active anticancer agent. Antiproliferative agent-20 exhibits antiproliferative and anti-angiogenic activities .

HY-152091

Antiproliferative agent-18	Fungal	Infection Cancer
Antiproliferative agent-18 (Compound 5k) is an anti-proliferative agent. Antiproliferative agent-18 also displays moderate anti-bacterial and anti-fungi activity .

HY-N8676

Antiproliferative agent-29	Others	Cancer
Antiproliferative agent-29 (Compound 16) is a triterpenoid isolated from the seeds of Peganum harmala L. Antiproliferative agent-29 has antiproliferative activity and has potential for cancer research .

HY-N8677

Antiproliferative agent-28	Others	Cancer
Antiproliferative agent-28 (Compound 14) is a triterpenoid isolated from the seeds of Peganum harmala L. Antiproliferative agent-28 has antiproliferative activity and has potential for cancer research .

HY-128224

Antiproliferative agent-13	Others	Cancer
Antiproliferative agent-13 (compound 16c) shows an antiproliferative activity against human A375 cells with an IC₅₀ value of 32.7 nM. Antiproliferative agent-13 can be used for the research of cancer .

HY-155402

Antiproliferative agent-42	Caspase Apoptosis	Others
Antiproliferative agent-42 (compound 7m) is a dihydrodipyrrolo compound. Antiproliferative agent-42 showed antiproliferative activity against Panc-1 cell line with an IC₅₀ value of 12.54 μM .

HY-148265

Antiproliferative agent-14	Microtubule/Tubulin	Cancer
Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC₅₀ of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle .

HY-150968

Antiproliferative agent-11	Apoptosis	Cancer
Antiproliferative agent-11 (compound 7) is an antiproliferative and selective Ruthenium(II)-Tris-pyrazolylmethane complex. Antiproliferative agent-11 shows antiproliferative activity towards MCF-7, HeLa, 518A2, HCT116 and RD with IC₅₀s of 6, 10, 6.8, 6.7 and 6 μM, respectively. Antiproliferative agent-11 can be used for the research of cancer .

HY-158016

Antiproliferative agent-49	EGFR Apoptosis	Cancer
Antiproliferative agent-49 (Compound 5a) is a EGFR-TK inhibitor with an IC₅₀ of 0.09 μM. Antiproliferative agent-49 is a anti-proliferative agent. Antiproliferative agent-49 displays good activities against HER3 and HER4 with IC₅₀ values 0.18 and 0.37 µM. Antiproliferative agent-49 induces mitochondrial apoptotic pathway and increased accumulation of ROS .

HY-N10067

Micromonosporamide A

Others Cancer

Micromonosporamide A exhibits glutamine-dependent antiproliferative activity.

Micromonosporamide A	Others	Cancer
Micromonosporamide A exhibits glutamine-dependent antiproliferative activity.

HY-W278944

Antiproliferative agent-15	Others	Cancer
Antiproliferative agent-15 is an anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines .

HY-115937

c-Met-IN-9	c-Met/HGFR Apoptosis	Cancer
c-Met-IN-9, a 4-phenoxypyridine derivative, is a c-Met kinas inhibitor with an IC₅₀ of 12 nM. c-Met-IN-9 induces cells apoptosis, and has antitumor activities .

HY-149780

Flavokawain 1i

DiNap
HSP Cancer

Flavokawain 1i (DiNap) is an Hsp90 inhibitor. Flavokawain 1i (DiNap) has anti-cell proliferation activity and can be used in cancer research .
HY-163381

Antiproliferative agent-48

Others Cancer

Antiproliferative agent-48 (compound PC-A1) shows selective antiproliferative activity against triple-negative breast cancer (TNBC) cells .

Flavokawain 1i DiNap	HSP	Cancer
Flavokawain 1i (DiNap) is an Hsp90 inhibitor. Flavokawain 1i (DiNap) has anti-cell proliferation activity and can be used in cancer research .

Antiproliferative agent-48	Others	Cancer
Antiproliferative agent-48 (compound PC-A1) shows selective antiproliferative activity against triple-negative breast cancer (TNBC) cells .

HY-146354

Antiproliferative agent-4	Apoptosis Reactive Oxygen Species	Cancer
Antiproliferative agent-4 (compound 2y) has excellent anti-proliferative activity against certain cancer cell lines. Antiproliferative agent-4 reduces the mitochondrial membrane potential, and increases the apoptosis rate and the level of ROS on EC109. Antiproliferative agent-4 inhibits tumour growth in nude mice, with low toxicity .

HY-162078

Antiproliferative agent-46	Casein Kinase	Cancer
Antiproliferative agent-46 (compound 5e) is an inhibitor of the casein kinase-2 enzyme (CK2) receptor. Antiproliferative agent-46 has a potent *antiproliferative* activity with an IC₅₀ value of 5.75 μM on the U87 cell line .

HY-N7279

Epiaschantin

(+)-Epiaschantin
Others Cancer

Epiaschantin is an anticancer agent. Epiaschantin shows antiproliferative activity .

HY-155112

Antiproliferative agent-30	Microtubule/Tubulin FLT3 Bcr-Abl	Cancer
Antiproliferative agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1. Antiproliferative agent-30 has vascular-disrupting activity. Antiproliferative agent-30 has broad antiproliferative activities against cancer cell lines (IC₅₀s: 0.054 nM, 0.008 nM, 0.144 nM for HCT-116, K562, MV-4-11 cells respectively). Antiproliferative agent-30 also has anticancer effect against AML with FLT3-ITD-TKD mutation .

HY-146103

Antiproliferative agent-7	Apoptosis Reactive Oxygen Species	Cancer
Antiproliferative agent-7 (compound 8f) is a potent anti-proliferative agent. Antiproliferative agent-7 has antiproliferative activity against cancer cell lines MCF-7, MDA-MB-231, HCT-116 and FR-2 with IC₅₀s of 3.5 μM, 15.54 μM, 30.43 μM and 34.8 μM, respectively. Antiproliferative agent-7 can increase ROS production and induce apoptosis .

HY-N3988

Hannokinol

Others Cancer

Hannokinol is a potent anti-tumor agent. Hannokinol shows antiproliferative activity. Hannokinol shows antioxidant activities .

Cat. No.	Product Name	Target	Research Area

HY-N6689

Destruxin A	Antibiotic	Infection Cancer
Destruxin A (DA) is a cyclo-peptidic mycotoxin from the entomopathogenic fungus Metarhizium anisopliae, with insecticidal, anti-viral and antiproliferative activities .

HY-W039102

N-Fmoc-N,O-dimethyl-L-serine	Amino Acid Derivatives	Cancer
N-Fmoc-N,O-dimethyl-L-serine is a serine derivative that can be used for coibamide A synthesis. Coibamide A is a marine natural product with potent antiproliferative activity against human cancer cells .

HY-P2228

Chlamydocin	HDAC Apoptosis	Cancer
Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC₅₀ of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3 .

HY-131923

DAPM	Notch	Cancer
DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells .

HY-P3990

Coibamide A	VEGFR Autophagy Apoptosis	Cancer
Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts .

HY-P2282

APTSTAT3-9R 1 Publications Verification	STAT	Cancer
APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity .

HY-16381

Pasireotide SOM230	Somatostatin Receptor	Endocrinology Cancer
Pasireotide (SOM230), a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pK_i=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide also exhibits antisecretory, antiproliferative, and proapoptotic activity .

HY-16381A

Pasireotide acetate 1 Publications Verification SOM230 acetate	Somatostatin Receptor	Endocrinology Cancer
Pasireotide (SOM230) acetate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pK_i=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide acetate can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide acetate also exhibits antisecretory, antiproliferative, and proapoptotic activity .

HY-163001

Microcolin H	Autophagy p62 Atg8/LC3	Cancer
Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N11916

Kadsuphilin A	Structural Classification Natural Products Source classification Kadsura philippinensis Elmer Plants Schisandraceae	Others
Kadsuphilin A can be extracted from Kadsura coccinea (Lem.) and has weak antiproliferative activity .

HY-N1107

Uzarigenin NSC 119993; NSC 277290; Odorigeni	Apocynaceae Structural Classification Cardiacglycosides Source classification Plants Steroids	Others
Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC₅₀ values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively .

HY-118834

Teleocidin A1 Lyngbyatoxin A	Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids Cancer	PKC
Teleocidin A1 (Lyngbyatoxin A), a highly toxic skin irritant, is a potent activator of protein kinase C (PKC). Teleocidin A1 shows antiproliferative activity against HeLa cancer cells (IC₅₀=9.2 nM) .

HY-N9093

(3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane	Source classification Phenols Curcuma kwangsiensis S. K. Lee & C. F. Liang Plants Zingiberaceae	Others
(3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane, a diarylheptanoid from the rhizomes of Curcuma kwangsiensis, possesses a variety of biological and pharmacological activities including antioxidant, antihepa totoxic, anti-inflammatory, antiproliferative, antiemetic, and antitumor activities .

HY-N8676

Antiproliferative agent-29	Triterpenes Structural Classification Terpenoids Zygophyllaceae Source classification Peganum harmala Linn. Plants	Others
Antiproliferative agent-29 (Compound 16) is a triterpenoid isolated from the seeds of Peganum harmala L. Antiproliferative agent-29 has antiproliferative activity and has potential for cancer research .

HY-N8677

Antiproliferative agent-28	Triterpenes Structural Classification Terpenoids Zygophyllaceae Source classification Peganum harmala Linn. Plants	Others
Antiproliferative agent-28 (Compound 14) is a triterpenoid isolated from the seeds of Peganum harmala L. Antiproliferative agent-28 has antiproliferative activity and has potential for cancer research .

HY-N10067

Micromonosporamide A	Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Alkaloids Source classification Disease Research Fields Cancer	Others
Micromonosporamide A exhibits glutamine-dependent antiproliferative activity.

HY-N7279

Epiaschantin (+)-Epiaschantin	Structural Classification other families Hernandia nymphaeifolia (C. Presl) Kubitzki Source classification Lignans Phenylpropanoids Plants	Others
Epiaschantin is an anticancer agent. Epiaschantin shows antiproliferative activity .

HY-N3988

Hannokinol	Structural Classification Amomum tsaoko Crevost et Lemarie Source classification Phenols Polyphenols Plants Zingiberaceae	Others
Hannokinol is a potent anti-tumor agent. Hannokinol shows antiproliferative activity. Hannokinol shows antioxidant activities .

HY-N12282

Isovitexin 2′′-O-rhamnoside	Structural Classification Polysaccharides Flavonoids Tetrastigma hemsleyanum Diels et Gilg Flavones Source classification Plants Vitaceae Saccharides	Others
Isovitexin 2′′-O-rhamnoside, a phenolic, has antioxidant and antiproliferative activities .

HY-N0743

Senkyunolide A 2 Publications Verification	Natural Products Classification of Application Fields Source classification Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields Cancer	Others
Senkyunolide A, isolated from Ligusticum chuanxiong Hort, has cytoprotective and antiproliferative activities. Anti-tumor activity .

HY-N4313

Eriosematin	Monophenols Classification of Application Fields Leguminosae Flemingia philippinensis Merr. et Rolfe Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Plants Disease Research Fields	Apoptosis
Eriosematin is a compound from the roots of Flemingia philippinensis with antiproliferative activity and apoptosis-inducing property .

HY-N0009

Geniposide 5+ Cited Publications	Structural Classification Iridoids Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis	Amyloid-β Influenza Virus
Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.

HY-N0202

Atractylenolide II 2 Publications Verification Asterolide	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Astragalus caprinus L. Plants Compositae Disease Research Fields Cancer	Apoptosis
Atractylenolide II is a sesquiterpene compound isolated from the dried rhizome of Atractylodes macrocephala (Baizhu in Chinese); anti-proliferative activity.

HY-N6689

Destruxin A	Infection Structural Classification Microorganisms Classification of Application Fields Cyclopeptides Source classification Disease Research Fields Biological Pesticide Research Agricultural Research	Antibiotic
Destruxin A (DA) is a cyclo-peptidic mycotoxin from the entomopathogenic fungus Metarhizium anisopliae, with insecticidal, anti-viral and antiproliferative activities .

HY-N0944

(-)-Heraclenol	Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Others
(-)-Heraclenol is a derivative of furocoumarin isolated from Ducrosia anethifolia. (-)-Heraclenol shows antiproliferative and cytotoxic activities on cancer cell lines .

HY-N3355

Lupeolic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Commiphora mukul (Hook. ex Stocks) Engl. Plants Burseraceae	Others
Lupeolic acid can be isolated from Boswellia sacra. Lupeolic acid has anti-proliferative* activity and can be used in cancer research .*

HY-N8477

Isolupalbigenin	Structural Classification Flavonoids Source classification Maclura tricuspidata Carriere Plants Moraceae Isoflavones	NO Synthase
Isolupalbigenin is an inhibitor of NO. Isolupalbigenin has anti-proliferative activity on HL-60 cells with an IC₅₀ of 5.1 μM .

HY-W000427

Ethyl Orsellinate	Infection Classification of Application Fields Usnea diffracta Vain. Source classification Phenols Polyphenols Plants Disease Research Fields Usneaceae	Bacterial
Ethyl orsellinate is a lichen metabolite and a derivative of lecanoric acid with antiproliferative and antitumour activities . Ethyl Orsellinate is against A. salina for the cytotoxic activity with an LC₅₀ of 495 μM .

HY-N7611

7-Prenyloxyaromadendrin	Flavanonols Flavonoids other families Pterocaulon alopecuroides Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Others
7-Prenyloxyaromadendrin is a flavonoid from Pterocaulon alopecuroides with antitumor activity. 7-Prenyloxyaromadendrin shows good antiproliferative activity in tumor cell lines .

HY-N11136

Schizolaenone C	Structural Classification Flavonoids Paulownia tomentosa (Thunb.) Steud. Flavonones Source classification Phenols Polyphenols Scrophulariaceae Plants	Others
Schizolaenone C is a natural product that can be found in Schizolaena hystrix. Schizolaenone C exhibits anti-proliferative and anti-oxidative activities .

HY-N6871

Abietic acid	Infection Structural Classification Colophony Classification of Application Fields Pinaceae Ketones, Aldehydes, Acids Metabolic Disease Plants Inflammation/Immunology Disease Research Fields	Bacterial
Abietic acid, a diterpene isolated from Colophony, possesses antiproliferative, antibacterial, and anti-obesity properties. Abietic acid inhibits lipoxygenase activity for allergy treatment .

HY-N3527

Calyxin B	Structural Classification Alpinia blepharocalyx K. Schum. Source classification Phenols Polyphenols Plants Zingiberaceae	Others
Calyxin B can be extracted from the seeds of Alpinia blepharocalyx. Calyxin B has anti-proliferative activity and can be used in cancer research .

HY-111525

Monactin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields	Oxidative Phosphorylation Bacterial Antibiotic
Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity .

HY-N8174

Valeriandoid F	Valeriana jatamansi Jones Iridoids Classification of Application Fields Terpenoids Source classification Plants Valerianaceae Disease Research Fields Inflammation/Immunology	NO Synthase
Valeriandoid F is an iridoid, which potently inhibits NO production with an IC₅₀ value of 0.88 μM. Valeriandoid F has anti-inflammatory and antiproliferative activities .

HY-N3428

Kamebanin	Structural Classification Terpenoids Labiatae Source classification Artemisia monosperma Delile Diterpenoids Plants	Others
Kamebanin can be isolated from the leaves of Isodon weisiensis C. Y. Wu. Kamebanin has anti-proliferative activity and can be used in cancer research .

HY-N10393

Vibsanin A	Structural Classification Natural Products Classification of Application Fields Viburnaceae Source classification Viburnum awabuki K. Koch Plants Disease Research Fields Cancer	PKC HSP
Vibsanin A, a protein kinase C (PKC) activator, exhibits anti-proliferative activity against human cancer cell lines. Vibsanin A is also a HSP90 inhibitor .

HY-N11108

Gochnatiolide A	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Gochnatia polymorpha (Less) Cabr.	Others
Gochnatiolide A is a dimeric sesquiterpene that can be found in Ainsliaea henryi. Gochnatiolide A exhibits antiproliferative activity against the kidney, melanoma, ovarian-resistant and glioma cell lines .

HY-N6621

Hippeastrine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Narcissus tazetta Linn. var. chinensis M.Roemer Source classification Plants Disease Research Fields Amaryllidaceae Cancer	Topoisomerase
Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC₅₀ at 7.25 μg/mL. Antiproliferative and anticancer activities .

HY-114646

TMC-205	Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids Cancer	Endogenous Metabolite
TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter .

HY-N6005

Methyl caffeate	Infection Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Solanum torvum Swartz Phenylpropanoids Plants Solanaceae Disease Research Fields	Bacterial
Methyl caffeate, an antimicrobial agent, shows moderate antimicrobial and prominent antimycobacterial activities. Methyl caffeate also exhibits α-glucosidase inhibition activity, oxidative stress inhibiting activity, anti-platelet activity, antiproliferative activity in cervix adenocarcinoma and anticancer activity in lung and leukmia cell lines .

HY-N3980

Guaiol Champacol; Guaiac alcohol	Infection Natural Products Classification of Application Fields Source classification Distemonanthus benthamianus Baill. Plants Compositae Disease Research Fields	Autophagy
Guaiol is a sesquiterpene alcohol that has been found in several traditional Chinese medicinal plants and has antiproliferative, pro-autophagic, insect repellent, and insecticidal biological activities .

HY-119502

Camalexin 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Camelina sativa (L.) Crantz Plants Endogenous metabolite Indole Alkaloids Infection Alkaloids Human Gut Microbiota Metabolites Microorganisms Brassicaceae Disease Research Fields	Reactive Oxygen Species Fungal Bacterial
Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production .

HY-N10670

Bursehernin Methylpluviatolide	Structural Classification Hernandia sonora Linn. other families Source classification Lignans Phenylpropanoids Plants	Apoptosis
Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin induces Apoptosis and cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity .

HY-118384

Sangivamycin 2 Publications Verification NSC 65346; BA-90912	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	PKC Nucleoside Antimetabolite/Analog
Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an K_i of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers .

HY-N12601

Diselaginellin B	Structural Classification Source classification Phenols Polyphenols Selaginella pulvinata (Hook. & Grev.) Maxim. Selaginellaceae Plants	Apoptosis
Diselaginellin B (compound 2) is a natural product isolated from Selaginella Pulvinata, which exhibits anti-proliferative, apoptosis-inducing and antimetastatic activities against human carcinoma hepatocellular cells .

HY-N7640

Deoxylimonin	Triterpenes Microorganisms Classification of Application Fields Citrus paradisi Macf. Terpenoids Source classification Rutaceae Plants Disease Research Fields Inflammation/Immunology	Others
Desoxylimonin is an orally active triterpenoid compound found from grapefruit seed. Desoxylimonin shows anti-proliferative activities to breast cancer cells. Desoxylimonin derivatives shows better anticancer, analgesic and anti-inflammatory activity than the lead compound .

HY-N2959

Brevilin A 3 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Euchresta horsfieldii (Lesch.) J. Benn. Plants Compositae Disease Research Fields Cancer	JAK STAT Apoptosis Autophagy
Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC₅₀= 10.6 µM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy .

HY-N10392

(S)-Erypoegin K	Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Erythrina poeppigiana Plants Disease Research Fields Isoflavones Cancer	Apoptosis
(S)-Erypoegin K is a potent anticancer agent. (S)-Erypoegin K shows potent anti-proliferative activity against HL-60 cells. (S)-Erypoegin K induces apoptosis .

HY-N10660

Dictyostatin (-)-Dictyostatin; Dictyostatin 1	Marine natural products Sponge	Microtubule/Tubulin
Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule stabilizing agent. Dictyostatin also is a anti-cancer agent. Dictyostatin shows antiproliferative activity. Dictyostatin has the potential for the research of tauopathies .

HY-N3215

Nagilactone C	Structural Classification Terpenoids Source classification Diterpenoids Podocarpus sellowii Klotzsch ex Endl. Plants Podocarpaceae	Others
Nagilactone C is a diterpene dilactone compound isolated from Podocarpus neriifolius. Nagilactone C has potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines .

HY-N0578

Apigenin 7-glucoside 2 Publications Verification Apigenin-7-O-β-D-glucopyranoside; Cosmosiin; Apigetrin	Flavonoids Classification of Application Fields Flavones Source classification Dendranthema morifolium (Ramat.) Tzvel. Phenols Polyphenols Plants Compositae Disease Research Fields Cancer	Reactive Oxygen Species
Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside) exhibits significant anti-proliferative and antioxidant activity and scavenges reactive oxygen species (ROS) .

HY-N11501

7-epi-Isogarcinol	Structural Classification Natural Products Garcinia xanthochymus Hook. f. ex T. Anders. Source classification Guttiferae Plants	STAT Apoptosis
7-epi-Isogarcinol is a polycyclic polyprenylated acylphloroglucinol (PPAP), with moderate antiproliferative activity. 7-epi-Isogarcinol blocks STAT3 signaling pathway, to induce apoptosis and inhibit cell migration .

HY-N8846

dl-Aloesol	Structural Classification Flavonoids Microorganisms Source classification Other Flavonoids	Fungal
dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .

HY-N3646

Cudratricusxanthone A	Structural Classification Flavonoids Source classification Maclura tricuspidata Carriere Plants Moraceae Other Flavonoids	Others
Cudratricusxanthone A is isolated from Cudrania tricuspidata, and has anti-inflammatory, hepatoprotective, and anti-proliferative activities. Cudratricusxanthone A inhibits osteoclast differentiation and function in RAW 264.7 cells and mouse bone marrow monocytes .

HY-129337

Reveromycin A	Infection Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Antibiotic Fungal Apoptosis
Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity .

HY-120607

Chevalone C	Infection Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Disease Research Fields	Parasite
Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC₅₀ value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines .

HY-N3451

Isothymusin	Structural Classification Flavonoids Classification of Application Fields Flavones Labiatae Source classification Balsamorhiza macrophylla Nutt. Plants Disease Research Fields Cancer	Lipoxygenase
Isothymusin is a potent anti-oxidant agent. Isothymusin shows radical scavenging activities. Isothymusin shows anti-proliferative activities in cancer cell lines. Isothymusin inhibited the enzymes associated with the promotion stage of cancer, including cycloxygenase- 2 and lipoxygenase-5 .

HY-N7085

Citropten 5,7-Dimethoxycoumarin; Limettin	Structural Classification Natural Products Classification of Application Fields Rutaceae Plants Disease Research Fields Cancer Citrus medica Linn. var. sarcodactylis (Noot.) Swingle	Others
Citropten (5,7-Dimethoxycoumarin) is a coumarin isolated from bergamot oil. Citropten (5,7-Dimethoxycoumarin) has an antiproliferative activity against A2058 human melanoma cell line .

HY-N3845

Ergosterol peroxide	Natural Products Classification of Application Fields Orchidaceae Source classification Plants Disease Research Fields Inflammation/Immunology Anoectochilus elwesii	Bacterial
Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities .

Cat. No.	Product Name	Chemical Structure

HY-N0005S

Curcumin-d6
Curcumin-d₆is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

HY-B0421S

Mycophenolic acid-d3

Mycophenolic acid-d₃ is deuterium labeled Mycophenolic acid, which is an an immunosuppresant agent and has potent anti-proliferative activity.

HY-142283AS

Dosimertinib mesylate
Dosimertinib-d₅ (mesylate) is a potent and orally active EGFR inhibitor. Dosimertinib-d₅ (mesylate) decreases the expression of p-EGFR and p-ERK protein levels. Dosimertinib-d₅ (mesylate) shows antiproliferative and anti-tumor activity. Dosimertinib-d₅ (mesylate) has the potential for the research of non-small-cell lung cancer (NSCLC)[1].

HY-17037S1

Pirenzepine-d8 dihydrochloride

Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-15605S

Encorafenib-13C,d3
Encorafenib- ¹³C,d₃ is the ¹³C- and deuterium labeled Encorafenib. Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM).

HY-A0143S

Dihomo-γ-linolenic acid-d6
Dihomo-γ-linolenic acid-d₆ (DGLA-d₆) is the deuterium labeled Dihomo-γ-linolenic acid. Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].

HY-B0965AS

Thioridazine-d3 hydrochloride

Thioridazine-d₃ (hydrochloride) is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].

HY-142283

Dosimertinib
Dosimertinib-d₃-d₃ is a potent and orally active EGFR inhibitor. Dosimertinib-d₃-d₃ decreases the expression of p-EGFR and p-ERK protein levels. Dosimertinib-d₃-d₃ shows antiproliferative and anti-tumor activity. Dosimertinib-d₃-d₃ has the potential for the research of non-small-cell lung cancer (NSCLC)[1].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks